BackgroundThis study aimed to examine glycolysis/gluconeogenesis-related genes in hepatocellular carcinoma (HCC) and evaluate their potential roles in HCC progression and immunotherapy response.MethodsData analyzed in this study were collected from GSE14520, GSE76427, GSE174570, The Cancer Genome Atlas (TCGA), PXD006512, and GSE149614 datasets, met
Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes
Summary: The high thermogenic activity of brown adipose tissue (BAT) has received considerable attention.Here, we demonstrated the role of the mevalonate (MVA) read more biosynthesis pathway in the regulation of brown adipocyte development and survival.The inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme in t
The Impact of Foreign Direct Investment Inflow on the Socio-Economic Upgrading of Nigeria
The research determined if the inflow of foreign direct investment has a significant impact on the socio-economic upgrading of the Nigerian economy.Standard of living and job creation served as measures of socio-economic development.The methodology adopted involved the use of multiple regression analysis to assess secondary emtek 2113 time series d
Continuous cover forestry: possible implications for surface water acidification in the UK uplands
The effects of widespread conifer afforestation on the acidity of lakes and streams in the acid sensitive uplands of the UK has been researched extensively and has contributed to the development and implementation of national forest management guidelines (e.g.Forest and Water Guidelines; Forestry Commission, 1993).However, a recent policy document